Circulation-active 4-aminoaryldihydropyridine lactones

ABSTRACT

4 Aminoaryldihydropyridines of the formula ##STR1## in which R 1  is hydrogen or an organic radical, preferably methyl or ethyl, 
     R 2  is hydrogen, C 1  -C 5  -alkyl, --CN, --NH 2 , --CH 2  or --CH 2  OH, preferably methyl, 
     R 3  is hydrogen or alkyl, preferably hydrogen, 
     Y is --CO-- or --SO 2  --, and 
     R 4  is an organic radical, or 
     Y--R 4  is hydrogen, 
     and physiologically acceptable salts thereof, are circulation-active and effective for improving myocardial contractility, for raising blood pressure, for lowering blood sugar, for reducing mucosal swelling and for controlling the salt and fluid balance.

The invention relates to 4-aminoaryl-dihydropyridine lactones, toprocess for their preparation and to their use in medicaments, inparticular in medicaments affecting the circulation.

The present invention relates to new 4-aminoaryl-dihydropyridines of thegeneral formula (I) ##STR2## in which

R¹ represents hydrogen or represents a straight-chain, branched orcyclic, saturated or unsaturated, hydrocarbon radical which has up to 15carbon atoms and is optionally substituted by C₁ -C₁₀ -alkoxy, C₁ -C₁₀-alkylthio, C₁ -C₁₀ -alkylsulphonyl, halogen, cyano, hydroxyl,morpholinyl, piperidyl, piperazinyl, by a group of the formula ##STR3##in which R⁵ and R⁶ are identical or different and represent hydrogen,represent C₁ -C₁₀ -alkyl, represent C₆ -C₁₄ -aryl, represent C₇ -C₁₄-aralkyl or represent C₂ -C₇ -acyl, or by an aryl or heteroaryl radical,the aryl or heteroaryl radicals optionally being substituted by 1 to 3identical or different substituents from the group comprising halogen,C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy, C₁ -C₆ -alkylthio, C₁ -C₆-alkyl-sulfonyl, hydroxyl, cyano, nitro, amino, C₁ -C₆ -alkylamino,di-C₁ -C₆ -alkylamino, trifluoromethyl or trifluoromethoxy,

R² represents C₁ -C₅ -alkyl, hydrogen, --CN, --NH₂, --CHO or --CH₂ OH,

R³ represents hydrogen or represent straight-chain, branched or cyclicC₁ -C₆ -alkyl which is optionally substituted by morpholino,

X represents hydrogen or represents halogen,

Y represents the group ##STR4## or --SO₂ -- and

R⁴ represents a straight-chain, branched or cyclic, saturated orunsaturated, hydrocarbon radical which has up to 20 C atoms and isoptionally substituted by halogen, or represents C₆ -C₁₄ -aryl which isoptionally substituted up to three times, identically or differently, byhalogen, C₁ -C₈ -alkyl, C₁ -C₈ -alkoxy, C₁ -C₈ -alkylthio, C₁ -C₈-halogenoalkyl having up to 5 halogen atoms, nitro, cyano, C₁ -C₈-alkylsulphonyl or by the group ##STR5## R⁷ and R⁸ having the meaningindicated for R⁵ and R⁶ and being identical to or different from thelatter, or represents pyridyl, thienyl, furyl, pyrimidyl, pyrazinyl,quinolyl or isoquinolyl, each of which is optionally substituted by C₁-C₆ -alkyl, C₁ -C₆ -alkoxy, halogen, cyano, nitro or di-C₁ -C₆-alkylamino, or represents C₇ -C₁₄ -aralkyl, the aryl radical optionallybeing substituted by up to three identical or different substituentsfrom the series comprising halogen, nitro, cyano, C₁ -C₄ -alkyl or C₁-C₄ -alkoxy, or represents a group of the formula ##STR6## R⁹ and R¹⁰having the meaning indicated for R⁵ and R⁶ and being identical to ordifferent from the latter, or the group --Y--R⁴ denotes hydrogen, in theform of their isomers, isomer mixtures, racemates and optical antipodes,and to their physiologically acceptable salts.

The substances according to the invention have agood-contractility-increasing and positive inotropic effect on theheart.

Preferred compounds of the general formula (I) are those in which

R¹ represents a straight-chain, branched or cyclic aliphatic hydrocarbonradical which has up to 10 C atoms and is optionally substituted by C₁-C₆ -alkoxy, C₁ -C₆ -alkylsulphonyl, one or more fluorine, chlorine,bromine, cyano or hydroxyl, by a group of the formula ##STR7## in whichR⁵ and R⁶ are identical or different and represent hydrogen, representC₁ -C₆ -alkyl, represents phenyl or benzyl, or represent acetyl orbenzoyl, or by phenyl, pyridyl, thienyl, furyl, pyrimidyl, quinolyl orisoquinolyl, it being possible for the phenyl and heteroaryl radicals tocarry up to three identical or different substituents from the seriescomprising fluorine, chlorine, bromine, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy,cyano, nitro, di-C₁ -C₄ -alkylamino or trifluoromethyl,

R¹ represents hydrogen, C₁ -C₅ -alkyl or --CN, R³ represents hydrogen orrepresents straight-chain or branched C₁ -C₄ -alkyl,

X represents hydrogen or represents fluorine, chlorine or bromine,

Y represents the group ##STR8## or --SO₂, and

R⁴ represents a straight-chain, branched or cyclic, saturated orunsaturated, hydrocarbon radical which has up to 15 carbon atoms and isoptionally substituted by one or more fluorine or chlorine, orrepresents phenyl which is optionally substituted once to three times,identically or differently, by fluorine, chlorine, bromine, C₁ -C₆-alkyl, C₁ -C₆ -alkoxy, C₁ -C₄ -halogenoalkyl having up to 5 halogenatoms, nitro, cyano, C₁ -C₄ -alkylsulphonyl or by a group of the formula##STR9## in which R⁷ and R⁸ have the meaning indicated for R⁵ and R⁶ andare identical to or different from the latter, or represents benzyl orphenethyl, or represents pyridyl, thienyl, furyl, quinolyl or pyrimidyl,each of which is optionally substituted by fluorine, chlorine, C₁ -C₄-alkyl, C₁ -C₄ -alkoxy, cyano, nitro or dimethylamino, or represents thegroup ##STR10## R⁹ and R¹⁰ having the meaning indicated for R⁵ and R⁶and possibly being identical to or different from the latter, or thegroup --Y--R⁴ denotes hydrogen, in the form of their isomers, isomermixtures, racemates or optical antipodes and in the form of theirphysiologically acceptable salts.

Particularly preferred compounds of the formula (I) are those in which

R¹ represents a straight-chain, branched or cyclic aliphatic hydrocarbonradical which has up to 6 carbon atoms and is optionally substituted byC₁ -C₃ -alkoxy, fluorine, chlorine, cyano, hydroxyl, the group of theformula ##STR11## in which

R⁵ and R⁶ are identical or different and represent hydrogen, representC₁ -C₄ -alkyl, represent phenyl or benzyl, or represent acetyl, or byphenyl, pyridyl, quinolyl or pyrimidyl, it being possible for the phenyland the heteroaryl radicals to be substituted by fluorine, chlorine,methyl, methoxy, cyano, nitro or trifluoromethyl,

R² represents hydrogen, C₁ -C₄ -alkyl or cyano,

R³ represents hydrogen,

X represents hydrogen or fluorine,

Y represents the group ##STR12## or --SO₂ --, and

R⁴ represents a straight-chain, branched or cyclic alkyl or alkenylradical which has up to 10 carbon atoms and is optionally substituted byone or more fluorine or chlorine, or represents phenyl which isoptionally substituted up to twice, identically or differently, byfluorine, chlorine, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄-halogenoalkyl, nitro, cyano or by di-C₁ -C₄ -alkylamino, or representsbenzyl, or represents pyridyl, furyl, thienyl or quinolyl, each of whichis optionally substituted by fluorine, chlorine, methyl, methoxy ornitro, or represents the group of the formula ##STR13## in which R⁹ andR¹⁰ have the meaning indicated for R⁵ and R⁶ and are identical to ordifferent from the latter, or the group --Y--R⁴ denotes hydrogen, in theform of their isomers, isomer mixtures, racemates or optical antipodesand in the form of their physiologically acceptable salts.

The substances according to the invention can exist in the form of theirsalts. In general, these are salts of the substances according to theinvention with inorganic or organic acids. However, the physiologicallyacceptable salts of the substances according to the invention withinorganic and organic acids are preferred. Examples which may bementioned are: hydrohalides, hydrogen sulphates, sulphates, hydrogenphosphates, acetates, maleates, citrates, fumarates, tartrates, lactatesor benzoates.

The compounds according to the invention exist in stereoisomeric formswhich either are related as image and mirror image (enantiomers) or arenot related as image and mirror image (diastereomers). The inventionrelates to both the antipodes and the racemic forms as well as mixturesof diastereomers. The racemic forms can be resolved in exactly the sameway as the mixtures of the diastereomers into the stereoisomericallyhomogeneous constituents in a known manner (compare E. L. Eliel,Stereochemistry of Carbon Compounds, Mc Graw Hill, 1962).

The compounds of the general formula (I) according to the invention areobtained when nitro compounds of the general formula (I) ##STR14## inwhich

R¹, R², R³ and X have the abovementioned meaning, are reduced, whereappropriate in the presence of a catalyst, where appropriate in thepresence of an acid, and where appropriate in the presence of an inertsolvent, in a manner known per se to give amino compounds of the generalformula (III) ##STR15## in which

R¹, R², R³ and X have the abovementioned meaning, and, where appropriatein a second step, the compounds of the formula (III) are reacted withcompounds of the general formula IV

    R.sup.4 --Y--Z                                             (IV)

in which

R⁴ and Y have the abovementioned meaning, and

Z represents halogen, preferably chlorine or bromine, or represents agroup --O--Y--R⁴,

where appropriate in the presence of a base, and where appropriate inthe presence of an inert solvent.

When the starting materials used are methyl2-methyl-4-(3-nitrophenyl)-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylateand benzoyl chloride or p-tosyl chloride, the reaction can beillustrated by the diagram which follows: ##STR16##

The compounds of the formula (II) which are used as starting materialsare known or can be prepared by known methods (DE-OS (German PublishedSpecification) No. 3,206,671).

The reduction in the first reaction step is carried out in a mannerknown per se, preferably by hydrogenation using metal catalysts such as,for example, platinum, palladium, palladium on animal charcoal or Raneynickel in the presence of acids.

The acids which can be used according to the invention are strongmineral acids as well as organic acids. Hydrogen halide acids such asHCl or HBr, sulphuric acid, phosphoric acid, perchloric acid, aceticacid, trifluoroacetic acid or p-toluenesulphonic acid are preferred.

The catalyst for this is generally used in an amount of 0.1 to 50 mol-%,preferably of 1 to 10 mol-%, relative to the nitro compound.

The hydrogenation is generally carried out in the temperature range from-20° to +100° C., preferably in the range from 0° to +50° C.

In general, the hydrogenation is carried out with an excess pressure of5 to 100 bar, preferably of 10 to 80 bar. It is equally possible tocarry out the hydrogenation under atmospheric pressure.

Suitable solvents for the hydrogenation are water and/or inert organicsolvents. These preferably include alcohols such as methanol, ethanol,propanol or isopropanol, ethers such as diethyl ether, dioxane,tetrahydrofuran, glycol monomethyl ether or glycol dimethyl ether,chlorinated hydrocarbons such as methylene chloride, chloroform orcarbon tetrachloride, glacial acetic acid, dimethylformamide, ethylacetate or acetone. It is equally possible to use mixtures of the saidsolvents.

The reduction is particularly preferably carried out with Raney nickelin alcohols with an excess pressure of hydrogen.

However, it is equally possible to carry out the reduction with metalssuch as zinc, tin or iron in the presence of acids such as acetic acidor hydrochloric acid as described by R. Scnroter in Houben-Weyls"Methoden der organischen Chemie" ("Methods of Organic Chemistry") XI/1,pages 363 et seq.

Suitable solvents in the second reaction step are inert organic solventswhich are not changed under the reaction conditions. These preferablyinclude ethers such as diethyl ether, dioxane, tetrahydrofuran, glycolmonomethyl ether or glycol dimethyl ether, chlorinated hydrocarbons suchas methylene chloride, chloroform, carbon tetrachloride or1,2-dichloroethane, or hydrocarbons such as benzene, toluene, xylene,hexane or petroleum fractions. It is equally possible to use mixtures ofthe said solvents.

Suitable bases are the customary organic bases. These preferably includetrialkylamines such as triethylamine or pyridine, quinoline,isoquinoline, methylpiperidine or methylmorpholine. It is equallypossible to use inorganic bases such as sodium or potassium carbonate,as well as alcoholates such as sodium ethylate, sodium methylate,potassium ethylate or potassium methylate. Triethylamine is particularlypreferably used.

The reaction is carried out in a temperatre range from 0° C. to 100° C.,preferably from 10° to 50° C.

The reaction can be carried out under atmospheric pressure as well asunder elevated or reduced pressure. In general, it is carried out underatmospheric pressure.

The compounds according to the invention exhibit a valuable spectrum ofpharmacological actions which could not have been predicted. They can beused as cardiotonics for improving myocardial contractility.Furthermore, they can be used as antihypotensives, for lowering bloodsugar, for reducing mucosal swelling and for influencing the salt andfluid balance.

The action increasing myocardial contractility was found in isolatedatria of guineapig hearts.

For this purpose, the left atria of guineapig hearts are isolated andsuspended in a thermostated organ bath which contains an isotonicmaterial salt solution which is adjusted to the ionic environment andthe pH of body fluids and contains suitable nutrients. A gas mixtureconsisting of oxygen and carbon dioxide was passed through this organbath, the carbon dioxide content being adjusted so that the pH of theorgan bath remains constant. The left atria were clamped in the organbath, and the tension was recorded by a force sensor, a particular basictone being set up. Then the left atria received continual electricalstimuli at set intervals, and the contractions taking place during thiswere recorded. At a concentration of 10⁻⁶ g/ml there is an increase incontractility compared with the initial figure which is set equal to100%.

    ______________________________________                                        Compound of  Increase in contractility                                        Example No.  at 10.sup.-6 g/ml                                                ______________________________________                                        6            +47%                                                             7            +80%                                                             8            +42%                                                             28           +33%                                                             29           +140%                                                            ______________________________________                                    

The new active compounds can be converted in a known manner into thecustomary formulations, such as tablets, capsules, coated tablets,pills, granules, aerosols, syrups, emulsions, suspensions and solutions,using inert, non-toxic, pharmaceutically suitable vehicles or solvents.The therapeutically active compounds should in each case be present in aconcentration of about 0.5 to 90% by weight of the total mixture, thatis to say in amounts which suffice to achieve the dosage rangeindicated.

The formulations are prepared, for example, by extending the activecompounds with solvents and/or vehicles, optionally with the use ofemulsifiers and/or dispersing agents, and, for example, when using wateras a diluent, organic solvents can optionally be used as auxiliarysolvents.

Examples of auxiliaries which may be mentioned are: water, non-toxicorganic solvents, such as paraffins (for example petroleum fractions),vegetable oils (for example groundnut oil/sesame oil, alcohols (forexample ethyl alcohol and glycerol) and glycols (for example propyleneglycol and polyethylene glycol), solid vehicles, such as, for example,natural rock powders (for example kaolins, aluminas, talc and chalk),synthetic rock powders (for example highly disperse silica andsilicates) and sugars (for example sucrose, lactose and glucose),emulsifiers (for example polyoxyethylene fatty acid esters,polyoxyethylene fatty alcohol ethers, alkylsulphonates andarylsulphonates), dispersing agents (for example lignin, sulphite wasteliquors, methylcellulose, starch and polyvinylpyrrolidone) andlubricants (for example magnesium stearate, talc, stearic acid andsodiumlaurylsulphate).

Administration is effected in the customary manner, preferably orally orparenterally, in particular perlingually or intravenously. In the caseof oral administration, the tablets can, of course, also contain, inaddition to the vehicles mentioned, additives such as sodium citrate,calcium carbonate and dicalcium phosphate, together with variousadditional substances, such as starch, preferably potato starch,gelatine and the like. Furthermore, lubricants such as magnesiumstearate, sodium lauryl sulphate and talc can also be used when makingtablets. In the case of aqueous suspensions and/or elixirs which areintended for oral use, the active compounds can be mixed with variousflavor-improving agents or colorants in addition to the abovementionedauxiliaries.

In the case of parenteral administration, solutions of the activecompounds, employing suitable liquid vehicles, can be used.

In general, it has proved advantageous, in the case of intravenousadministration, to administer amounts of about 0.001 to 1 mg/kg,preferably about 0.01 to 0.5 mg/kg, body weight to achieve effectiveresults, and in the case of oral administration, the dosage is about0.01 to 20 mg/kg, preferably 0.1 to 10 mg/kg, body weight.

Nevertheless, it can at times be necessary to deviate from the amountsmentioned, and in particular to do so as a function of the body weightof the experimental animal or of the nature of the administrationmethod, but also because of the species of animal and its individualbehavior towards the medicament, or the nature of the formulation of themedicament and the time or interval over which the administration takesplace. Thus it can suffice in some cases to manage with less than theabovementioned minimum amount, while in other cases the upper limitmentioned must be exceeded. Where relatively large amounts areadministered, it can be advisable to divide these into severalindividual administrations over the course of the day. The same dosagerange is envisaged for administration in human medicine. In thisconnection, the above statements similarly apply.

PREPARATION EXAMPLES Example 1Ethyl-4-(2-aminophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3carboxylate##STR17##

58 mmol of ethyl4-(2-nitrophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylateare dissolved in 200 ml of tetrahydrofuran, and 2 g of Raney nickel areadded. Hydrogenation is carried out under a pressure of 50 bar of H₂ for1.5 h. The solution is evaporated, and dilute hydrochloric acid is addedand the product is filtered off with suction and dried. Yield: 56% oftheory

Melting point: 175°-183° C.

The following were prepared in analogy to Example 1.

Example 2 Methyl4-(2-aminophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate##STR18##

Yield: 80% of theory.

Melting point: 193-5° C.

Example 3 Butyl4-(2-aminophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate##STR19##

Yield: 60% of theory.

Melting point: 167-9° C.

Example 4 Ethyl4-(3-aminophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate##STR20##

Yield: 80% of theory.

Melting point: 179°-181° C.

Example 5 Ethyl4-(2-benzoylamino)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate##STR21##

10 mmol of ethyl4-(2-aminophenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylateare dissolved in 100 ml of CH₂ Cl₂, and 3 3 ml of triethylamine (20mmol) are added. 10 mmol of benzoyl chloride are added to this solution.The mixture is stirred at room temperature for 1.5-2.0 hours. Thesolution is extracted by shaking 1× with H₂ O, and the organic phase isdried with Na₂ SO₄ or molecular sieve and is evaporated. Crystals areobtained from methanol or ethanol.

Yield: 80% of theory.

Melting point: 275° C.

The examples in the tables which follow were prepared in analogy toExample 5:

                  TABLE 1                                                         ______________________________________                                         ##STR22##                                                                    Ex-                                                                           am-                                     Melting                               ple                                     point                                 No.  R.sup.1  R.sup.3                                                                             XY    R.sup.4       [°C.]                          ______________________________________                                         6   CH.sub.3 H     HCO                                                                                  ##STR23##    >270                                   7   CH.sub.3 H     HCO                                                                                  ##STR24##    >270                                   8   CH.sub.3 H     HCO                                                                                  ##STR25##    >270                                   9   CH.sub.3 H     HCO                                                                                  ##STR26##    235-6                                 10   CH.sub.3 H     HCO                                                                                  ##STR27##    220-2                                 11   CH.sub.3 H     HCO                                                                                  ##STR28##    >270                                  12   CH.sub.2 CH.sub.3                                                                      H     HSO.sub.2                                                                            ##STR29##    115-20                                13   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR30##    233-7                                 14   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR31##    >250                                  15   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR32##    >250                                  16   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR33##    >250                                  17   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR34##    >250                                  18   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR35##    >250                                  19   CH.sub.2 CH.sub.3                                                                      H     HCO   CH.sub.2 CH.sub.3                                                                           >250                                  20   CH.sub.2 CH.sub.3                                                                      H     HCO   CH.sub.2CH(CH.sub.3).sub.2                                                                  228-30                                21   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR36##    183-5                                 22   CH.sub.2 CH.sub.3                                                                      H     HCO   (CH.sub.2).sub.7 CH.sub.3                                                                   167-70                                23   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR37##    >250                                  24   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR38##    >250                                  25   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR39##    >250                                  26   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR40##    >250                                  27   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR41##    >250                                  28   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR42##    >250                                  29   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR43##    >250                                  30   CH.sub.2 CH.sub.3                                                                      H     HCO                                                                                  ##STR44##    >250                                  31   n-C.sub.4 H.sub.9                                                                      H     HCO                                                                                  ##STR45##    232-5                                 32   n-C.sub.4 H.sub.9                                                                      H     HCO                                                                                  ##STR46##    225-7                                 33   n-C.sub.4 H.sub.9                                                                      H     HCO                                                                                  ##STR47##    148-55                                34   n-C.sub.4 H.sub.9                                                                      H     HCO                                                                                  ##STR48##    225-27                                35   n-C.sub.4 H.sub.9                                                                      H     HCO                                                                                  ##STR49##    203-4                                 36   n-C.sub.4 H.sub.9                                                                      H     HCO                                                                                  ##STR50##    234-6                                 ______________________________________                                    

                  TABLE 2                                                         ______________________________________                                         ##STR51##                                                                    Example                                  Melting                              No.    R.sup.1                                                                              R.sup.3                                                                             X   Y    R.sup.4     point [°C.]                   ______________________________________                                        37     C.sub.2 H.sub.5                                                                      H     H   CO                                                                                  ##STR52##  252-3                                38     C.sub.2 H.sub.5                                                                      H     H   CO                                                                                  ##STR53##  225-8                                39     C.sub.2 H.sub.5                                                                      H     H   CO                                                                                  ##STR54##  251-6                                ______________________________________                                    

It will be understood that the specification and examples areillustrative but not limitative of the present invention and that otherembodiments within the spirit and scope of the invention will suggestthemselves to those skilled in the art.

We claim:
 1. A 4-aminoaryldihydropyridine of the formula ##STR55## inwhich R¹ represents hydrogen or alkyl which has up to 15 carbon atomsand is optionally substituted by C₁ -C₁₀ -alkoxy or C₁ -C₁₀-alkylthio,R² represents hydrogen, C₁ -C₅ -alkyl, --CN, --NH₂, --CHO or--CH₂ OH, R³ represents hydrogen or represent straight-chain, branchedor cyclic alkyl of up to 6 carbon atoms, X represents hydrogen orrepresents halogen, R⁴ represents C₆ -C₁₄ -aryl which is optionallysubstituted up to three times, identically or differently, by halogen,C₁ -C₈ -alkyl, C₁ -C₈ -alkoxy, C₁ -C₈ -alkylthio, C₁ -C₈ -halogenalkylhaving up to 5 halogen atoms, nitro, cyano or C₁ -C₈ -alkylsulphonyl, orrepresents pyridyl, thienyl or furyl, each of which is optionallysubstituted by C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy, halogen, cyano, nitro ordi-C₁ -C₆ -alkylamino, or represents C₇ -C₁₄ -aralkyl, the aryl radicaloptionally being substituted by up to three identical or differentsubstituents from the group consisting of halogen, nitro, cyano, C₁ -C₄-alkyl or C₁ -C₄ -alkoxy,or a physiologically acceptable salt thereof.2. A 4-aminoaryldihydropyridine or salt according to claim 1, in whichR¹represents alkyl which has up to 10 C atoms and is optionallysubstituted by C₁ -C₆ -alkoxy, R² represents hydrogen, C₁ -C₅ -alkyl or--CN, R³ represents hydrogen or represents straight-chain or branched C₁-C₄ -alkyl, X represents hydrogen or represents fluorine, chlorine orbromine, R⁴ represents phenyl which is optionally substituted once tothree times, identically or differently, by fluorine, chlorine, bromine,C₁ -C₆ -alkyl, C₁ -C₆ -alkoxy, C₁ -C₄ -halogenoalkyl having up to 5halogen atoms, nitro, cyano or C₁ -C₄ -alkylsulphonyl, or representsbenzyl or phenethyl, or represents pyridyl, thienyl or furyl, each ofwhich is optionally substituted by fluorine, chlorine, C₁ -C₄ -alkyl, C₁-C₄ -alkoxy, cyano or nitro.
 3. A 4-aminoaryldihydropyridine or saltaccording to claim 1, in whichR¹ represents alkyl which has up to 6 Catoms and is optionally substituted by C₁ -C₃ -alkoxy, R² representshydrogen, C₁ -C₄ -alkyl or --CN, R³ represents hydrogen, X representshydrogen or represents fluorine, R⁴ represents phenyl which isoptionally substituted up to twice, identically or differently, byfluorine, chlorine, C₁ -C₄ -alkyl, C₁ -C₄ -alkoxy, C₁ -C₄-halogenoalkyl, nitro or cyano, or represents benzyl, or representspyridyl, furyl or thienyl, each of which is optionally substituted byfluorine, chlorine, methyl, methoxy or nitro.
 4. A4-aminoaryldihydropyridine according to claim 1, wherein such compoundis ethyl4-(2-benzoylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetra-hydrofuro[3,4-b]pyridine-3-carboxylateof the formula ##STR56## or a physiologically acceptable salt therof. 5.A 4-aminoaryldihydropyridine according to claim 1, wherein such compoundis methyl4-(2-p-chlorobenzoylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylateof the formula ##STR57## or a physiologically acceptable salt thereof.6. A 4-aminoaryldihydropyridine according to claim 1, wherein suchcompound is methyl4-(2-m-methylbenzoylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylateof the formula ##STR58## or a physiologically acceptable salt thereof.7. A 4-aminoaryldihydropyridine according to claim 1, wherein suchcompound is ethyl4-(2-phenacetylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylateof the formula ##STR59## or a physiologically acceptable salt thereof.8. A composition for improving myocardial contractility, for raisingblood pressure, for lowering blood sugar, for reducing mucosal swellingand for controlling the salt and fluid balance, which comprises anamount effective therefor of a compound or salt according to claim 1 anda diluent.
 9. A unit dose of a composition according to claim 8, in theform of a tablet, capsule or ampule.
 10. A method of improvingmyocardial contractility, of raising blood pressure, of lowering bloodsugar, of reducing mucosal swelling and of controlling the salt andfluid balance in a patient in need thereof, which comprisesadministering to such patient an amount effective therefor of a compoundor salt according to claim
 1. 11. The method according to claim 10,wherein such compound isethyl4-(2-benzoylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetra-hydrofuro[3,4-b]pyridine-3-carboxylate,methyl4-(2-p-chlorobenzoylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetra-hydrofuro[3,4-b]pyridine-3-carboxylate,methyl4-(2-m-methylbenzoylbenzoylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate,ethyl4-(2-phenacetylamino-phenyl)-2-methyl-5-oxo-1,4,5,7-tetrahydrofuro[3,4-b]pyridine-3-carboxylate.